general, abstract situation. On the other side, I know that graduate students and all mathematicians sometimes falter because their intuitive, ..

In education there is a concern that science teachers misrepresent the nature of science to students. An assumption that is implicit in this concern is that science teachers should be teaching the philosophy of science as it is understood by philosophers. This paper argues that both philosophers and science teachers misrepresent science when they engage in their respective disciplines, and it is evident the two misrepresentations are of different types. In philosophy, the misrepresentation is of a philosophical-epistemological nature where advocates (...) of particular views maintain that advocates of other views misinterpret the nature of science. In education, the misrepresentation is of a cognitive, teaching nature where teachers'' practical interpretations are not congruent with philosophers'' interpretations of science. The discrepancy that exists between the two misrepresentations is due to the intentions of the two disciplines, and assuming that science teachers should teach a philosophically coherent interpretation of the nature of science is an over-simplification of the problem. The concepts of espoused theories and theories-in-use are used to link the two interpretations of science and provide suggestions for future research that may help clarify misrepresentations of science in science education. (shrink)

When the whole is greater than the sum of the parts--indeed, so great that the sum far transcends the parts and represents something utterly new and different--we call that phenomenon emergence. When the chemicals diffusing in the primordial waters came together to form the first living cell, that was emergence. When the activities of the neurons in the brain result in mind, that too is emergence. In The Emergence of Everything, one of the leading scientists involved in the study of (...) complexity, Harold J. Morowitz, takes us on a sweeping tour of the universe, a tour with 28 stops, each one highlighting a particularly important moment of emergence. For instance, Morowitz illuminates the emergence of the stars, the birth of the elements and of the periodic table, and the appearance of solar systems and planets. We look at the emergence of living cells, animals, vertebrates, reptiles, and mammals, leading to the great apes and the appearance of humanity. He also examines tool making, the evolution of language, the invention of agriculture and technology, and the birth of cities. And as he offers these insights into the evolutionary unfolding of our universe, our solar system, and life itself, Morowitz also seeks out the nature of God in the emergent universe, the God posited by Spinoza, Bruno, and Einstein, a God Morowitz argues we can know through a study of the laws of nature. Written by one of our wisest scientists, The Emergence of Everything offers a fascinating new way to look at the universe and the natural world, and it makes an important contribution to the dialogue between science and religion. (shrink)

This work identifies Kant’s doctrine of inner sense as a central element within the ‘architectonic of pure reason’ of the first Critique, exposes its variant construals, and considers the implications of its problematicity for Kant’s theoretical philosophy most generally.

Youth ministry as a sub-discipline of practical theology has traditionally always had an ecclesial focus. The focus was often based on the practices of proselytisation and discipleship, a sort of ‘reach and teach’ model whereby Christian believers would do the ‘reaching and teaching’ of the ‘lost’ youth. This is most true in an evangelical context and is further undergirded by a Western concept of personal salvation nearly devoid of any communal responsibilities and context. The traditional model, therefore, in evangelical churches (...) was reaching the ‘lost’ with the Gospel of Jesus Christ, with the aim of personal salvation for the individual who would eventually become a member of the faith community through a discipleship programme. Thus, the beginning and end of the entire process were the focus on personal salvation devoid of any contextual consideration. Youth ministry as practical theology must move into the area of public theology to engage the practices inherited from the western model by engaging with the public (youths) as public theologians (those who influence the theologies of the youth), and the public faiths and spiritualities (the expression of the youth’s theologies) to be relevant to the majority and developing world.Contribution: In this study, the author suggests that this ‘reach and teach’ paradigm with an ecclesial focus in the context of the majority and developing world is no longer suitable to meet the needs of youth. In addition, the author recommends a more appropriate framework with youth ministry as public practical theology for consideration. (shrink)

There has been an increase of discussion and focus on matters of theological significance in the area of youth ministry. An area that remains neglected concerns the professional youth worker in Southern Africa. This focus on professional youth work has gained a great amount of urgency from the office of the presidency of Southern Africa, who in collaboration with the Commonwealth desk have prioritised the focus on youth work in South Africa. Unfortunately, the focus on the professional youth worker, the (...) career youth pastor, within the church in Southern Africa fails to receive a similar amount of attention. The article will highlight the need to pursue a theological articulation around the office of the career youth pastor by building a practical theological argument for the office of career youth pastor. The article will address a case study of a mainline evangelical denomination regarding its theological articulation of the career youth pastor. (shrink)

Leadership and areas of influence are often reserved for the adult community. The youth are mostly regarded as developing beings, with insufficient knowledge and experience to take on leadership roles where influence can be exercised. It is often considered – especially in the context of the church – that the youth do not have the capacity to lead, while evidence from society and research studies points to the contrary. The author of this article argues that the ability to influence does (...) not depend on age or in an accumulation of experience. Instead, the ability of the youth to make a difference is attributed to their desire to do so. The author draws attention to why we need to focus on the youth and their ability to make a difference. The article presents an argument based on scriptural evidence and a theology of childhood as to why it is indeed possible and beneficial for the youth to exert their influence across various sectors of society. (shrink)

J.N. Findlay was a South African philosopher who published from the late 1940s into the 1980s. He had a prestigious international academic career, holding many academic posts around the world. This article uses a textual comparative approach and focuses on Findlay’s Gifford Lecture at St Andrews University between 1965 and 1970. The objective of the article is to highlight the extent to which Findlay’s philosophical writings were influenced by Mahāyāna Buddhism. Although predominantly a Platonist, Findlay drew influence from Asian philosophy (...) and religion, particularly Mahāyāna Buddhism. In these lectures, he applies the metaphor of the Platonic Cave to investigate Hegelian and Husserlian approaches to knowledge. Though he was a leading Hegel and Husserl scholar, his reading of these two philosophers is strongly influenced by Mahāyāna Buddhism, resulting in a unique mystical interpretation of these two philosophers. Revisiting Findlay’s writings is significant for two reasons; firstly, he investigated Buddhism prior to the Asian religions being included in Religious Studies departments’ purview in South African universities, and secondly, his interpretation of two prominent Western philosophers along Buddhist lines provides an early attempt at decolonising the predominance of Western philosophical views of knowledge.Contribution: This contribution forms part of a larger collection of essays investigating philosophical works that have had a significant impact on the study of religion. This contribution investigates the Buddhist influence on J.N. Findlay’s philosophical readings of Husserl and Hegel. (shrink)

Hausman and McPherson provide an evidential defense of welfare economics, arguing that preferences are not constitutive of welfare but nevertheless provide the best evidence for what promotes welfare. Behavioral economics identifies several ways in which some people's preferences exhibit anomalies that are incoherent or inconsistent with rational choice theory. I argue that the existence of these behavioral anomalies calls into question the evidential defense of welfare economics. The evidential defense does not justify preference purification, or eliminating behavioral anomalies before conducting (...) welfare analysis. But without doing so, the evidential defense yields implausible welfare implications. I discuss how the evidential defense could be modified to accommodate behavioral anomalies. (shrink)

Harold Tarrant here explores ancient attempts to interpret Plato's writings, by philosophers who spoke a Greek close to Plato's own, and provides a fresh, ...

The genome is a stable repository of vastly intricate genetic information developed over eons of evolution; this information is replicated at the highest fidelity and expressed within each cell at the highest selectivity. Non‐leukemia cancers break this standard; the intricate genetic information qualitatively and progressively deteriorates, resulting in a somatic Darwinian free‐for‐all. In a process lasting several years, a genomically heterogeneous population replicates from a single cell that originally lost the ability to preserve its genomic integrity. Cells selected for their (...) abilities to proliferate and spread, while evading host defenses, inexorably expand their numbers. The clinical consequences of this become severe, as the genomically diverse cell population that evolves contains members that can evade most therapeutic approaches aimed at “the tumor cell”. BioEssays 23:1037–1046, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Charting a "middle way" between the extremes represented by Alvin Plantinga and Richard Swinburne, Garth Hallett explores the thesis that if belief in other minds is rational and true (as it surely is), so too is belief in God. He makes a strong case that when this parity claim is appropriately restricted to a single, sound other-minds belief, belief in God and belief in other minds do prove epistemically comparable. This result, and the distinctive path that leads to it, (...) will interest students and scholars in philosophy of religion and theology. (shrink)

This article is a response to recent revealing political attempts to set a political and social function for the Arts through the establishment of performance criteria. A long-standing feature of the historical development of government policy in the UK has been attempts to judge the effectiveness and efficiency of public activity by invidious comparison to effectiveness and efficiency in so-called ‘private’ industry. This tendency requires continuous critical scrutiny.

Although VL30 retrotransposable elements have been associated with certain cancers for nearly twenty years, because of their expression in rodent malignancies and recombination into murine sarcoma viruses, their causative role, if any, in cancer has been uncertain and enigmatic. Recent findings suggest loss of normal transcriptional control of specific VL30 element expression may make a critical contribution to tumor progression at a step associated with malignant conversion, by bringing into play a cellular program normally involved in wound healing. This program, (...) the fibroblast anoxic response system, includes an adaptation to glycolytic metabolism, secretion of metalloproteinases, and activation of an endonuclease. While appropriate for facilitating debris removal during wound healing, loss of control of this program in a cell which has already progressed to the benign neoplastic state has the potential to simultaneously produce the invasiveness and genomic instability charateristic of malignancy. Examination of tumors and tumor derived cell lines has confirmed that key aspects of this system are in fact activated in cancer. (shrink)

Internationally, the research on the education of boys has sought to understand how social practices, behaviours and rituals contribute to identity construction. We are interested in approa...

In partial fulfilment of the requirements for the degree of Doctor of Philosophy, Department of Secondary Education.

Tumor‐cell diversification mechanisms insure that malignant neoplasms contain diversified tumor‐cell subpopulations. Because of the instability of tumor cell phenotypes, some malignant cells will evolve with the most favorable properties for their progression to highly metastatic cells. The rates of cellular phenotypic diversification vary greatly among different tumors, and they are probably modulated, in part, by genetic and chromosome defects and by epigenetic events that may vary widely depending upon the nature of the tumor cells and their microenvironments. As tumor diversification (...) and selection proceed, the most malignant cell subpopulations may eventually become dominant and gradually lose their microenvironmental responsiveness. Tumor‐cell diversification mechanisms may be similar or identical to normal, developmentally regulated diversification mechanisms that are used during embryonic cell diversification and differentiation. (shrink)

Alterations in the expression of certain genes or in their products can render benign tumor cells metastatic. Experimentally this has been quickly performed by transferring dominantly acting oncogenes such as c‐H‐rasEJ into susceptible cells, but in vivo such a rapid qualitative change in a dominantly acting oncogene occurs only rarely, and progression to highly metastatic phenotypes is thought to occur through a slow stepwise process. Such slow changes can be reversible and need not involve known dominantly acting oncogenes, consistent with (...) clinical observations. An important element of the natural progression of tumors to malignancy may be their ability to circumvent microenvironmental controls that regulate growth and cellular diversity and to evolve into heterogeneous phenotypes, a process that appears to involve mainly quantitative changes in gene expression but which can be rapidly stimulated in cell culture by the introduction of a dominantly acting oncogene. It is proposed that the highly malignant cells that have slowly evolved in vivo with only a few qualitative gene changes have undergone extensive cycles of diversification and accumulation of quantitative changes in the expression of genes that encode products that are related to malignancy and metastasis. Thus, highly malignant cellular phenotypes can arise quickly through specific qualitative changes in critical controlling genes or more slowly by less critical qualitative genetic changes, coupled with cellular diversification and accumulation of quantitative changes in gene expression. (shrink)

Objective: A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines. Summary of key data: The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it. Conclusions: Future pandemic clinical trials systems should obtain dose optimisation data, as these (...) appear necessary to enable appropriate scarce resource allocation according to societal values. (shrink)

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Laski, Harold J. The Foundations of Sovereignty and Other Essays.

The assumption on which this volume is founded is that a proper comparison between scientific cognition and folk ways of thought rests on an adequate study of ...

Interpretation, Constraint, and the Prospects of Scientific Realism I explore the interaction between theory-based interpretations of scientific evidence and constraints on theories provided by that evidence. Interpretation is often viewed as a source of error and a reason for scepticism about scientific results. But, I argue, while interpretation does generate epistemic risk, it also points to new sources of evidence that can constrain our theories. This is especially clear in the development of instrumentation that increases the range of our interactions (...) with nature. While the design of such instruments and the interpretation of their outputs are deeply dependent on theory-based interpretations, these outputs can still challenge those very theories. At the same time, theory-guided instrumentation provides us access to aspects of nature that we cannot study with our unaided senses. This access allows us to extend the range of evidence that we collect, and thus increases the constraints on our theories. As a result, theory-guided evidence collection has a positive impact on the prospects of scientific realism since these increasing constraints on our theories provide our only reason for thinking that we may be approaching the development of true theories. (shrink)

Currently, boys growing up in urban poverty remain severely under-represented in Australian higher education. To explore this phenomenon, we draw on recent research with boys in Year 12 who will potentially be first-in-family as well as their teachers. The overarching research question framing the chapter is: “How do the school experiences of marginalized young men, living in one of the poorest urban regions in Australia, influence their transition to university?” Research on social mobility has documented that schooling plays a significant (...) role in how students transition to university, where school experiences can significantly influence the success of students from disadvantaged backgrounds. We draw on case study data from one school site, Chipple Senior College, located in the western suburbs of Sydney, to show how certain learner identities are cultivated through institutional tracking as well as teacher–student relationships concerning career guidance counselling and mentorship. Specifically, we identify certain divergences between how teachers view the transition journey of these boys, compared with how the boys themselves see it. The findings indicate discourses of gender—as well as institutional practices—play a significant role in orienting these young men toward their futures. (shrink)

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Another title in the reissued Oxford Classic Texts in the Physical Sciences series, Jeffrey's Theory of Probability, first published in 1939, was the first to develop a fundamental theory of scientific inference based on the ideas of Bayesian statistics. His ideas were way ahead of their time and it is only in the past ten years that the subject of Bayes' factors has been significantly developed and extended. Until recently the two schools of statistics were distinctly different and set apart. (...) Recent work has changed all that and today's graduate students and researchers all require an understanding of Bayesian ideas. This book is their starting point. (shrink)

This article describes two uses of folk psychology in scientific psychology. Use 1 deals with the way in which folk theories and beliefs are imported into social psychological models on the basis that they exert causal influences on cognition or behavior (regardless of their validity or scientific usefulness). Use 2 describes the practice of mining elements from folk psychology for building an overarching psychological theory that goes beyond common sense (and assumes such elements are valid or scientifically useful). This distinction (...) is then applied to both common practices within psychology and the philosophical arguments concerning the scientific validity of folk psychology. Adopting a social psychological perspective, I argue that (a) the two uses are often conflated in psychology with deleterious consequences; and (b) that the arguments for the elimination of folk psychology as a basis for scientific psychology presented by Churchland and others, are weakened by the failure to attend to this distinction. (shrink)

"One of the most impressive pieces of scholarship I have ever encountered."-W. E. Kennick, Amherst College There is nothing in the literature on the Philosophical Investigations comparable to this learned and exhaustive commentary. Offering both information and interpretation, it is a remarkable book that fills a recognized need for a close study of one of the world's major works of philosophy. After a general introduction, Father Hallett divides the text of the Investigations into forty-one units, and then provides an introduction (...) to each section, along with detailed comments on individual paragraphs, statements, and expressions. His use of paragraph numbers in the general introduction and in the sectional introductions permits ready reference downward, for detailed development or illustration of a general observation, or upward, from a particular passage to its wider context. To clarify the philosophical point of Wittgenstein's remarks, Father Hallett makes frequent references to other parts of the Investigations; to Wittgenstein's other writings, both published and unpublished; and to the works which Wittgenstein knew and often had in mind, such as those of Frege, Russell, Moore, James, Augustine, Plato, Schlick, and Kohler. Father Hallett also cites and quotes secondary sources, and he includes an appendix relating Wittgenstein to more than 150 authors, particularly those of his own generation or earlier whom he read, or knew personally, and who are mentioned in this commentary. Written in straightforward and lucid prose, this outstanding book reveals continuities in Wittgenstein's thought over long periods of time. It is an indispensable guide for those preparing courses on the Investigations and a useful tool for students taking those courses. (shrink)